Hello @LoryMoney,
Not knowing your background or skill set, I would take a look at some other threads.
CSS Grid and Flexbox have been used by others on this forum.
Namely @Brian_Radspinner , @BurningTreeC and @Mohammad and others.
Grid CSS in Tiddlywiki Demystified
Grid CSS to Create a Vertical Tab Like Structure
Grid CSS to Create Left Sidebar and a Story River
Tutorial: a basic alternative layout
TiddlyFlex - a new Flexbox Layout for TiddlyWiki
TiddlyFlex v0.7.12
I hope this may give you an idea on what can be achieved and adapted depending on your timescales.