I’m planning to use TW in conjunction with Lepiter from GToolkit, so the first can be our “(web) publishing platform” and the second can be our “(desktop) computing platform”. You can see more in this thread: TiddlyWikiPharo and critical code/data literacy curriculum. As @jeremyruston said there, they are orthogonal (but important common principles expressed in different ways, as told on that thread).
Programming, data manipulation and custom UI/UX can be done on Pharo/GT, and web publishing would be on TW. For that, improved WikiText parsers and interfaces need to be build, so Tiddlers can be edited directly inside TiddlyWikiPharo in a more friendly way and conversions between Markdown and WikiText are possible (but I have just started to learn parsers and I’m not a computer scientist or professional programmer). I also would like to export GT graph in TW using ECharts + TW. It will be a joyful exploration. We need to address some projects before this year, focusing on PDF reporting for data storytelling and social media. But because we are already using GT as our main computing environment and TW as our wiki engine, those experiments should improve the connection of TW and Pharo/GT ecosystems and communities.