If you are using NodeJS wiki already, you can try TidGi-Desktop , which can open nodejs wiki folder, and is optimized for huge wiki.
If you use TidGi desktop to creat a new wiki, it pre-install the TidMe plugin that is a Tiddlywiki-Native supermemo or Anki. Works best with in-wiki backlinks, and use FSRS algorithm that is better than Anki’s SM2 altgorithm.
By the way, my wiki is 3GB and have many images, and has nearly 30k tiddlers, I use TidGi desktop to open it.
Hope you can join the The 5,000 Tiddler Club – People with the Need for Speed one day.