Tiddlywiki has a tree macro which creates something like left panel in treeview windows 7
having preview pane can be implemented see: Grid CSS to Create a Vertical Tab Like Structure - Tips & Tricks - Talk TW (tiddlywiki.org)
By the way, I think the main factor here is time and money! There is no limitation or restriction on Tiddlywiki side! You can simple shape Tiddlywiki in many forms!