Since version 110 chrome has activated automatic unloading of background webpages to reclaim memory. If such a page is a tiddlywiki with unsaved work then this work will be lost. This can be disabled globally from:
settings->performance
This would apply to all pages. The individual listing of URLs to be ignore did not seem to work.
I have (just) quickly put together a browser extension that automatically tells chrome not to unload any tiddlywikis. This is obviously not rigorously tested, but you can try at your own risk: